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aspergillus fumigatus fresenius  (ATCC)


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    ATCC aspergillus fumigatus fresenius
    Aspergillus Fumigatus Fresenius, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 435 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/aspergillus+fumigatus/Aspergillus+fumigatus+Fresenius/custom%4046645%4042097148
    Average 96 stars, based on 435 article reviews
    aspergillus fumigatus fresenius - by Bioz Stars, 2026-10
    96/100 stars

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    Activity Assay:

    Article Title: Citrus Peel Flours: From Residues to Bioactive Ingredients for Food Applications
    Article Snippet: Typhimurium (ATCC 13311) and Enterobacter cloacae (ATCC 35030) were tested. .. Additionally, the antifungal activity was assessed against six micromycetes: Aspergillus fumigatus (human isolate), Aspergillus niger (ATCC 6275), Aspergillus versicolor (ATCC 11730), Penicillium funiculosum (ATCC 36839), Trichoderma viride (IAM 5061) and Penicillium verrucosum var. cyclopium (food isolate), using the methodology described by [34]. ..

    Article Title: Novel organophosphorus-quinolone hybrids as potential antimicrobial agents: design, synthesis, biological evaluation, and in vivo antibacterial effect in bacteria-infected zebrafish model.
    Article Snippet: 1 Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangdong Medical University, Zhanjiang 524023, China 2 School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China 3 Department of Pharmacy, Shenzhen Children’s Hospital, Shenzhen 518038, China Abstract A novel series of organophosphorus–quinolone hybrids were designed and synthesized as potential antimicrobial agents through efficient phospho-Mannich reactions.. The most potent compound, 5d, demonstrated exceptional activity against methicillin-resistant Staphylococcus aureus (MRSA) with an MIC of 0.5 μg/mL, representing a 16-fold and twofold improvement over norfloxacin and ciprofloxacin, respectively.. Structure–activity relationship studies revealed the critical influence of substituent electronic properties and steric bulk, with electron-donating groups enhancing potency.

    Bacteria:

    Article Title: First comprehensive GC–MS profile of Echinops erinaceus with antimicrobial and cytotoxic activities and in-silico model
    Article Snippet: Various species of micro-organisms: 10 bacterial strains; Gram-positive bacteria: B. subtilis (RCMB 015 (1) NRRL B-543), Staph. aureus (RCMB010010), Staph. epidermidis (RCMB 009 (2)), Strep. mutans (RCMB 017 (1) ATCC 25,175), and Strep. pyogenes (RCMB 01001 74–2). .. Gram-negative bacteria: E. coli (RCMB 010,052 ATCC 25,955), Kleb. pneumonia (RCMB 003 (1) ATCC 13,883), Proteus vulgaris (RCMB 004 (1) ATCC 13,315), Pseudomonas aeruginosa (RCMB 01,002 43–5), and Sal. typhimurium (RCMB 006 (1) ATCC 14,028); and 10 fungal strains: Aspergillus fumigatus (RCMB 002,008), A. niger (RCMB 002,005), C. albicans (RCMB 005,003 (1) ATCC 10,231), C. tropicalis (RCMB 005,004 (1)), Cryptococcus neoformans (RCMB 0,049,001), Geotrichum candidum (RCMB 05,097), Microsporum canis (RCMB 0834), Penicillium expansum (RCMB 001001 (2)), Syncephalastrum racemosum (RCMB 016,001 (1)), and Trichophyton mentagrophytes (RCMB 0925) were obtained as tested organisms by in the Microbiology Laboratory, Regional Centre for Mycology and Biotechnology, Al-Azhar University, Cairo, Egypt. ..

    Solubility:

    Article Title: Novel organophosphorus-quinolone hybrids as potential antimicrobial agents: design, synthesis, biological evaluation, and in vivo antibacterial effect in bacteria-infected zebrafish model.
    Article Snippet: 1 Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangdong Medical University, Zhanjiang 524023, China 2 School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China 3 Department of Pharmacy, Shenzhen Children’s Hospital, Shenzhen 518038, China Abstract A novel series of organophosphorus–quinolone hybrids were designed and synthesized as potential antimicrobial agents through efficient phospho-Mannich reactions.. The most potent compound, 5d, demonstrated exceptional activity against methicillin-resistant Staphylococcus aureus (MRSA) with an MIC of 0.5 μg/mL, representing a 16-fold and twofold improvement over norfloxacin and ciprofloxacin, respectively.. Structure–activity relationship studies revealed the critical influence of substituent electronic properties and steric bulk, with electron-donating groups enhancing potency.

    other:

    Article Title: Innate lymphoid cells integrate sensing and plasticity to control fungal infections
    Article Snippet: Additional fungal strains included Candida albicans SC5314 (ATCC MYA-2876), Candida auris (CBS 10913; provided by Neeraj Chauhan), Aspergillus fumigatus (ATCC 204305), and a GFP-expressing A. fumigatus strain114 (CBS 101355).



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    aspergillus fumigatus fresenius  (ATCC)
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    Image Search Results


    Aspergillus fumigatus (n=85) identified from soil samples collected from different states of India. The gray bars represent the number of susceptible isolates, and the red bars represent the number of azole-resistant Aspergillus fumigatus isolates. Aspergillus fumigatus was classified as resistant (R), when MIC was above the following ECV values: itraconazole >1 μg/mL, voriconazole >1 μg/mL, and posaconazole >0.25 μg/mL.

    Journal: Frontiers in Fungal Biology

    Article Title: Understanding multi-azole resistance in Aspergillus fumigatus : the impact of non- cyp51A mutation and efflux pump overexpression

    doi: 10.3389/ffunb.2026.1830942

    Figure Lengend Snippet: Aspergillus fumigatus (n=85) identified from soil samples collected from different states of India. The gray bars represent the number of susceptible isolates, and the red bars represent the number of azole-resistant Aspergillus fumigatus isolates. Aspergillus fumigatus was classified as resistant (R), when MIC was above the following ECV values: itraconazole >1 μg/mL, voriconazole >1 μg/mL, and posaconazole >0.25 μg/mL.

    Article Snippet: Relative expression levels were calculated in comparison with the susceptible A. fumigatus strain (ATCC 46645). indicates the two-fold relative expression of crucial genes in ARAF isolates compared to the susceptible isolate of A. fumigatus (ATCC 46645).

    Techniques:

    Distribution of Aspergillus fumigatus isolates based on the minimum inhibitory concentration (MIC) values (n=85). Vertical dashed lines indicate the epidemiological cutoff values (ECVs) for itraconazole (1 µg/mL), voriconazole (1 µg/mL), and posaconazole (0.25 µg/mL). Isolates with MIC values < ECV were classified as susceptible (S), whereas those with MIC values > ECV were categorized as resistant (R). The gray bars represent the number of susceptible isolates, and the red bars represent the number of azole-resistant Aspergillus fumigatus isolates.

    Journal: Frontiers in Fungal Biology

    Article Title: Understanding multi-azole resistance in Aspergillus fumigatus : the impact of non- cyp51A mutation and efflux pump overexpression

    doi: 10.3389/ffunb.2026.1830942

    Figure Lengend Snippet: Distribution of Aspergillus fumigatus isolates based on the minimum inhibitory concentration (MIC) values (n=85). Vertical dashed lines indicate the epidemiological cutoff values (ECVs) for itraconazole (1 µg/mL), voriconazole (1 µg/mL), and posaconazole (0.25 µg/mL). Isolates with MIC values < ECV were classified as susceptible (S), whereas those with MIC values > ECV were categorized as resistant (R). The gray bars represent the number of susceptible isolates, and the red bars represent the number of azole-resistant Aspergillus fumigatus isolates.

    Article Snippet: Relative expression levels were calculated in comparison with the susceptible A. fumigatus strain (ATCC 46645). indicates the two-fold relative expression of crucial genes in ARAF isolates compared to the susceptible isolate of A. fumigatus (ATCC 46645).

    Techniques: Concentration Assay

    Ribbon representations of superimpositions of modeled (A-C) mutated Cyp51A protein structure with the wild-type protein of A. fumigatus. The green color structure represents the wild-type Cyp51A proteins.

    Journal: Frontiers in Fungal Biology

    Article Title: Understanding multi-azole resistance in Aspergillus fumigatus : the impact of non- cyp51A mutation and efflux pump overexpression

    doi: 10.3389/ffunb.2026.1830942

    Figure Lengend Snippet: Ribbon representations of superimpositions of modeled (A-C) mutated Cyp51A protein structure with the wild-type protein of A. fumigatus. The green color structure represents the wild-type Cyp51A proteins.

    Article Snippet: Relative expression levels were calculated in comparison with the susceptible A. fumigatus strain (ATCC 46645). indicates the two-fold relative expression of crucial genes in ARAF isolates compared to the susceptible isolate of A. fumigatus (ATCC 46645).

    Techniques:

    Relative expression of cyp51A (A) , cyp51B (B) and hmg1 (C) genes in azole-resistant environmental isolates relative to that in susceptible A fumigatus (wild type ATCC 46645). β-tubulin was used as a housekeeping gene to normalize transcription levels. Data reported as mean of fold changes with standard deviation from three independent experiments amplified in triplicates. Green color bars represent upregulation while red bars represent downregulation of genes. **** p < 0.0001.

    Journal: Frontiers in Fungal Biology

    Article Title: Understanding multi-azole resistance in Aspergillus fumigatus : the impact of non- cyp51A mutation and efflux pump overexpression

    doi: 10.3389/ffunb.2026.1830942

    Figure Lengend Snippet: Relative expression of cyp51A (A) , cyp51B (B) and hmg1 (C) genes in azole-resistant environmental isolates relative to that in susceptible A fumigatus (wild type ATCC 46645). β-tubulin was used as a housekeeping gene to normalize transcription levels. Data reported as mean of fold changes with standard deviation from three independent experiments amplified in triplicates. Green color bars represent upregulation while red bars represent downregulation of genes. **** p < 0.0001.

    Article Snippet: Relative expression levels were calculated in comparison with the susceptible A. fumigatus strain (ATCC 46645). indicates the two-fold relative expression of crucial genes in ARAF isolates compared to the susceptible isolate of A. fumigatus (ATCC 46645).

    Techniques: Expressing, Standard Deviation, Amplification

    Relative expression of mdr4 (A) , mfsC (B) , cdr1B (C) , mdr1 (D) , and abcA (E) genes in azole-resistant environmental isolates relative to that in susceptible A fumigatus (wild type ATCC 46645) β-tubulin was used as a housekeeping gene to normalize transcription levels. Data reported as mean of fold changes with standard deviation from three independent experiments amplified in triplicates. Green color bars represents upregulation while red bars represents downregulation of genes. **** p < 0.0001.

    Journal: Frontiers in Fungal Biology

    Article Title: Understanding multi-azole resistance in Aspergillus fumigatus : the impact of non- cyp51A mutation and efflux pump overexpression

    doi: 10.3389/ffunb.2026.1830942

    Figure Lengend Snippet: Relative expression of mdr4 (A) , mfsC (B) , cdr1B (C) , mdr1 (D) , and abcA (E) genes in azole-resistant environmental isolates relative to that in susceptible A fumigatus (wild type ATCC 46645) β-tubulin was used as a housekeeping gene to normalize transcription levels. Data reported as mean of fold changes with standard deviation from three independent experiments amplified in triplicates. Green color bars represents upregulation while red bars represents downregulation of genes. **** p < 0.0001.

    Article Snippet: Relative expression levels were calculated in comparison with the susceptible A. fumigatus strain (ATCC 46645). indicates the two-fold relative expression of crucial genes in ARAF isolates compared to the susceptible isolate of A. fumigatus (ATCC 46645).

    Techniques: Expressing, Standard Deviation, Amplification

    Heatmap of gene expression in ARAF isolates, illustrating the correlation between cyp51A mutations, efflux pump gene expression, and azole resistance profiles. The left panel lists the cyp51A mutations present in each isolate. Novel mutations are in red letters. The middle panel presents a heatmap showing the expression levels of genes associated with azole resistance ( cyp51A, cyp51B, hmg1, mdr1, mdr4, mfsC, cdr1B , and abcA ) across different isolates. The color scale indicates the relative expression, with blue representing downregulation and red representing upregulation compared to the susceptible control isolate ( A. fumigatus ATCC 46645). The right panel provides an overview of the azole resistance profiles of each isolate, categorized by resistance to itraconazole, voriconazole, and posaconazole. The gray boxes indicate resistance to the corresponding drug, while white boxes indicate susceptibility. This comprehensive overview highlights the complex interplay between genetic mutations and gene expression that contribute to azole resistance in A. fumigatus .

    Journal: Frontiers in Fungal Biology

    Article Title: Understanding multi-azole resistance in Aspergillus fumigatus : the impact of non- cyp51A mutation and efflux pump overexpression

    doi: 10.3389/ffunb.2026.1830942

    Figure Lengend Snippet: Heatmap of gene expression in ARAF isolates, illustrating the correlation between cyp51A mutations, efflux pump gene expression, and azole resistance profiles. The left panel lists the cyp51A mutations present in each isolate. Novel mutations are in red letters. The middle panel presents a heatmap showing the expression levels of genes associated with azole resistance ( cyp51A, cyp51B, hmg1, mdr1, mdr4, mfsC, cdr1B , and abcA ) across different isolates. The color scale indicates the relative expression, with blue representing downregulation and red representing upregulation compared to the susceptible control isolate ( A. fumigatus ATCC 46645). The right panel provides an overview of the azole resistance profiles of each isolate, categorized by resistance to itraconazole, voriconazole, and posaconazole. The gray boxes indicate resistance to the corresponding drug, while white boxes indicate susceptibility. This comprehensive overview highlights the complex interplay between genetic mutations and gene expression that contribute to azole resistance in A. fumigatus .

    Article Snippet: Relative expression levels were calculated in comparison with the susceptible A. fumigatus strain (ATCC 46645). indicates the two-fold relative expression of crucial genes in ARAF isolates compared to the susceptible isolate of A. fumigatus (ATCC 46645).

    Techniques: Gene Expression, Expressing, Control